People

John T. Ngo, Ph.D.

Assistant Professor of Biomedical Engineering

[jtngo@bu.edu]
['Author File' in Nature Methods]

I was the first my family to finish high school and the first to earn a Ph.D. My training in research began at UC Santa Barbara, where I characterized enzymes involved in biosilica formation in the “orange puffball sponge” Tethya aurantium. As a graduate student at Caltech, I developed cell-targeted methods to track de novo protein synthesis in neurons, tissues, and in vivo. After my Ph.D., I trained with Roger Tsien on probe development for imaging cells via correlative light and electron microscopy (CLEM). At Boston University, my lab investigates mechanisms of signal transduction at cell-cell interfaces. Our current efforts are focused on Notch signal transduction, in which we seek to understand how mechanical tension is delivered to and sensed by Notch receptors for the regulation their protease sensitivity and signaling activities. Students from the lab have received several awards and honors, including the BME Thesis of the Year Award and the College of Engineering's Earle and Mildred Bailey Memorial Award, among others.