Molecular Engineering for Cell Biology and Biotechnology

We study how molecules are organized within and between cells, with the goal of understanding how changes in organization give rise to dynamic biological processes. In pursuit of this goal, we develop tools to dissect and control when and where proteins exist, and to track and manipulate the interactions they make with other biomolecules. Our work draws upon principles from chemistrybiophysics, and evolution, and trainees in our lab gain expertise in protein structure, cell signaling, and cell engineering. Our projects can be categorized into one or more of the following synergistic themes:

(1) Engineering & understanding Notch mechanotransduction

(2) Design of new inducible systems for cell biology & SynBio 

(3) Development of novel imaging probes for visualizing molecular interactions in cells